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The Merbl Lab

The ubiquitin-proteasome system in cancer and immune regulation 

Standing at the intersection of Biochemistry, Proteomics, and Immunology, our lab studies proteostasis regulation in cancer and immunity. Maintaining protein homeostasis is a crucial cellular task involving an extensive protein network of more than 1,000 proteins that are responsible for sensing and responding to cellular stress, to allow proper function of our proteome.  We focus primarily on two aspects of proteostasis control namely, regulatory mechanisms of protein post-translational modifications (PTMs) and degradation in health and disease. Read More

 

Our group employs advanced high-throughput immuno-proteomic, proteomics and genomic methods, cell biology, biochemistry and in-vivo models to reveal new proteostasis control mechanisms. 

We combine our expertise to gain novel insight on basic research questions as well as develop cutting-edge technologies to transform our ability to analyze the proteomic landscape. Importantly, we aim for translating our findings into clinical applications and therapeutic interventions to promote human health. Read More

 

We are always looking for enthusiastic, motivated and talented people, at all career stages, to join our team!