Publications

The Merbl Lab

The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate anti-tumor immunity in NSCLC

Javitt A*, Shmueli MD*, Kramer MP, Kolodziejczyk A, Cohen I, Radomir L, Sheban D, Kamer I, Litchfield K, Bab-Dinitz E, Zadok O, Neiens V, Ulman A, Wolf-Levy H, Eisenberg-Lerner A, Kacen A, Alon M, Toste Rêgo A, Stacher-Priehse E, Lindner M, Koch I, Bar J, Swanton C, Samuels Y, Levin Y, da Fonseca P, Elinav E, Friedman N, Meiners S, Merbl Y.

Nature Cancer. DOI: 10.1038/s43018-023-00557-4.

Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration

Benyair R, Giridharan SSP, Rivero-Ríos P, Hasegawa J, Bristow E, Eskelinen EL, Shmueli MD, Fishbain-Yoskovitz V, Merbl Y, Sharkey LM, Paulson HL, Hanson PI, Patnaik S, Al-Ramahi I, Botas J, Marugan J, Weisman LS.

Autophagy Rep. 2023. DOI: 10.1080/27694127.2023.2166722

EMSY stabilization in KEAP1-mutant lung cancer disrupts genome stability and type I interferon signaling.
Sheban D, Merbl Y.

Cell Death Differ. 2023. DOI: 10.1038/s41418-023-01150-z

Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.
Zheng D, Mohapatra G, Kern L, He Y, Shmueli MD, Valdés-Mas R, Kolodziejczyk AA, Próchnicki T, Vasconcelos MB, Schorr L, Hertel F, Lee YS, Rufino MC, Ceddaha E, Shimshy S, Hodgetts RJ, Dori-Bachash M, Kleimeyer C, Goldenberg K, Heinemann M, Stettner N, Harmelin A, Shapiro H, Puschhof J, Chen M, Flavell RA, Latz E, Merbl Y, Abdeen SK, Elinav E.

Nat Immunol. 2023. DOI: 10.1038/s41590-023-01450-z

Large-Scale Immunopeptidome Analysis Reveals Recurrent Posttranslational Splicing of Cancer- and Immune-Associated Genes.
Levy R, Alter Regev T, Paes W, Gumpert N, Cohen Shvefel S, Bartok O, Dayan-Rubinov M, Alon M, Shmueli MD, Levin Y, Merbl Y, Ternette N, Samuels Y.

Mol Cell Proteomics. 2023. DOI: 10.1016/j.mcpro.2023.100519

Post-translational modifications reshape the antigen landscape of the MHCI immunopeptidome in tumors
Kacen A, Javitt A, Kramer MP, Morgenstern D, Tsaban T, Teo GC, Leprevost F, Barnea E, Yu F, Admon A, Schueler-Furman O, Levin Y, Nesvizhskii AI, Merbl Y.

Nature Biotech. DOI: 10.1038/s41587-022-01464-2

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Mazor RD, Nathan N, Gilboa A, Stoler-Barak L, Moss L, Solomonov I, Hanuna A, Divinsky Y, Shmueli MD, Hezroni H, Zaretsky I, Mor M, Golani F, Sabah G, Jakobson-Setton A, Yanichkin N, Feinmesser M, Tsoref D, Salman L, Yeoshoua E, Peretz E, Erlich I, Mendelson Cohen N, Gershoni MJ, Freund N, Merbl Y, Yaari G, Eitan R, Sagi I, Shulman Z.

Cell. 2022. DOI: 10.1016/j.cell.2022.02.012.

Maintaining Golgi Homeostasis: A Balancing Act of Two Proteolytic Pathways.
Benyair R, Eisenberg-Lerner A, Merbl Y.

Cells. 2022. DOI: 10.3390/cells11050780.

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

Sheban D, Shani T, Maor R, Alejandro AC, Nofar M, Jakob H, Sergey V, Shmueli MD, Vladislav K, Chugaeva V, Rodriguez de Larosa A, Zerbib M, Ulman A, Massarwa S, Kupervaser M, Levin Y, Shema E, David Y, Novershtern N, Hanna JH, Merbl Y.

Molecular Cell. Jan 6;82(1):106-122.e9. DOI: 10.1016/j.molcel.2021.11.011.

Altered protein abundance and localization inferred from sites of alternative modification by ubiquitin and SUMO

Ulman A, Levin T, Dassa B, Javitt A, Kacen A, Fishllevich S, Sheban D, Levy E, Merbl Y.

JMB. 2021. DOI: 10.1016/j.jmb.2021.167219

Gatekeepers of the Gut: The Roles of Proteasomes at the Gastrointestinal Barrier.
Mohapatra G, Eisenberg-Lerner A, Merbl Y.

Biomolecules. 2021. DOI: 10.3390/biom11070989.

Histone degradation by the proteasome regulates chromatin and cellular plasticity.
Shmueli MD, Sheban D, Eisenberg-Lerner A, Merbl Y.

FEBS J. 2021. DOI: 10.1111/febs.15903.

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis.
Marmor-Kollet H, Siany A, Kedersha N, Knafo N, Rivkin N, Danino YM, Moens TG, Olender T, Sheban D, Cohen N, Dadosh T, Addadi Y, Ravid R, Eitan C, Toth Cohen B, Hofmann S, Riggs CL, Advani VM, Higginbottom A, Cooper-Knock J, Hanna JH, Merbl Y, Van Den Bosch L, Anderson P, Ivanov P, Geiger T, Hornstein E.

Mol Cell. 2020. DOI: 10.1016/j.molcel.2020.10.032

Golgi organization is regulated by proteasomal degradation

Eisenberg-Lerner A, Benyair R, Hizkiahou N, Nudel N, Maor R, Kramer MP, Shmueli MD, Zigdon I, Cherniavsky Lev M, Ulman A, Sagiv JY, Dayan M, Dassa B, Rosenwald M, Shachar I, Li J, Wang Y, Dezorella N, Khan S, Porat Z, Shimoni E, Avinoam O, Merbl Y.

Nat Communications. 2020. DOI:10.1038/s41467-019-14038-9.

Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

Reznik N, Kozer N, Eisenberg-Lerner A, Barr H, Merbl Y, London N.

ACS Chem Biol. 2019. https://doi.org/10.1021/acschembio.9b00667

Global views of proteasome-mediated degradation by mass spectrometry.
Javitt A, Merbl Y.

Expert Rev Proteomics. 2019, DOI: 10.1080/14789450.2019.1651979.

Global views of proteasome-mediated degradation by mass spectrometry.
Javitt A, Merbl Y.

Expert Rev Proteomics. 2019. doi: 10.1080/14789450.2019.1645601.

Pro-inflammatory cytokines alter the immunopeptidome landscape by modulation of HLA-B expression

Javitt A, Wolf-Levy H, Barnea E, Admon A, Merbl Y.

Front. Immunol, 2019. DOI: 10.3389/fimmu.2019.00141

Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides

Wolf-Levy H, Javitt A, Eisenberg-Lerner A, Kacen A, Ulman A, Sheban D, Dassa B, Fishbain-Yoskovitz V, Carmona-Rivera C, Kramer MP, Nudel N, Regev I, Zahavi L, Elinger D, Kaplan MJ, Morgenstern D, Levin Y, Merbl Y.

Nature Biotech, 2018. DOI: 10.1038/nbt.4279

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Mor N, Rais Y, Sheban D, Peles S, Aguilera-Castrejon A, Zviran A, Elinger D, Viukov S, Geula S, Krupalnik V, Zerbib M, Chomsky E, Lasman L, Shani T, Bayerl J, Gafni O, Hanna S, Buenrostro JD, Hagai T, Masika H, Vainorius G, Bergman Y, Greenleaf WJ, Esteban MA, Elling U, Levin Y, Massarwa R, Merbl Y, Novershtern N, Hanna JH.

Cell Stem Cell. 2018. https://doi.org/10.1016/j.stem.2018.07.004

Post-Translational Modification Profiling-Functional Proteomics for the Analysis of Immune Regulation

Eisenberg-Lerner A, Regev I, Merbl Y.

Methods Mol Biol. 2017. DOI: 10.1007/978-1-4939-7201-2_9. PubMed PMID: 28809000.

Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer

Eisenberg-Lerner A, Ciechanover A, Merbl Y.

Exp Biol Med. 2016. https://doi.org/10.1177/1535370216651732

Post-Translational Modification Profiling--a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems.
Merbl Y, Kirschner MW.

Curr Protoc Protein Sci. 2014. doi: 10.1002/0471140864.ps2708s77.

Microarray Discovery of New OGT Substrates:bThe Medulloblastoma Oncogene OTX2 Is O-GlcNAcylated

Ortiz-Meoz R, Merbl Y, Kirschner MW, Walker S.

J Am Chem Soc. 2013.https://doi.org/10.1021/ja500451w