The Merbl Lab



Global views of proteasome-mediated degradation by mass spectrometry.

Javitt A, Merbl Y.

Expert Rev. Proteomics. (2019) 1–6. doi:10.1080/14789450.2019.1651979

Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression.

Javitt A, Barnea E, Kramer MP, Wolf-Levy H, Levin Y, Admon A, Merbl Y.

Front Immunol (2019) 10:141. doi:10.3389/fimmu.2019.00141

Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides.

Wolf-Levy H, Javitt A, Eisenberg-Lerner A, Kacen A, Ulman A, Sheban D, Dassa B, Fishbain-Yoskovitz V, Carmona-Rivera C, Kramer M P, Nudel N, Regev I, Zahavi L, Elinger D, Kaplan M J, Morgenstern D, Levin Y, Merbl Y.

Nature Biotechnology. Oct 2018; doi:10.1038/nbt.4279

Post Translational Modification Profiling- FunctionalProteomics for Analysis of Immune Regulation.

Eisenberg-Lerner A, Regev I, Merbl Y.

Methods in Molecular Biology. Jan 2017, 1647:139-152. 10.1007/978-1-4939-7201-2_9

Post-translational modification profiling – A novel tool for mapping the protein modification landscape in cancer.

Eisenberg-Lerner A, Ciechanover A, Merbl Y. ‚Äč

Experimental Biology and Medicine, 2016 Apr. 241(14):1475-82. 

Post-Translational Modification Profiling-a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. 

Merbl Y, Kirschner MW.

Curr Protoc Protein Sci. 2014 Aug 1;77:27.8.1-27.8.13. doi: 10.1002/0471140864.ps2708s77.

PMID: 25081743

Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. 

Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S.

J Am Chem Soc. 2014 Apr 2;136(13):4845-8. doi: 10.1021/ja500451w. Epub 2014 Mar 17.


Individual and meta-immune networks.

Bransburg-Zabary S, Kenett DY, Dar G, Madi A, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E.

Phys Biol. 2013 Apr;10(2):025003. doi: 10.1088/1478-3975/10/2/025003. Epub 2013 Mar 15.


Profiling of ubiquitin-like modifications reveals features of mitotic control.

Merbl Y, Refour P, Patel H, Springer M, Kirschner MW.

Cell. 2013 Feb 28;152(5):1160-72. doi: 10.1016/j.cell.2013.02.007.


Analyses of antigen dependency networks unveil immune system reorganization between birth and adulthood.

Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Boccaletti S, Tauber AI, Cohen IR, Ben-Jacob E.

Chaos. 2011 Mar;21(1):016109. doi: 10.1063/1.3543800.


Network theory analysis of antibody-antigen reactivity data: the immune trees at birth and adulthood.

Madi A, Kenett DY, Bransburg-Zabary S, Merbl Y, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E.

PLoS One. 2011 Mar 8;6(3):e17445. doi: 10.1371/journal.pone.0017445.


Protein microarrays for genome-wide posttranslational modification analysis.

Merbl Y, Kirschner MW.

Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun;3(3):347-56. doi: 10.1002/wsbm.120. Epub 2010 Sep 23. Review.


UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex.

Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1355-60. doi: 10.1073/pnas.0912802107. Epub 2010 Jan 6.


Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data.

Madi A, Hecht I, Bransburg-Zabary S, Merbl Y, Pick A, Zucker-Toledano M, Quintana FJ, Tauber AI, Cohen IR, Ben-Jacob E.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14484-9. doi: 10.1073/pnas.0901528106. Epub 2009 Aug 10.


A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice.

Merbl Y, Itzchak R, Vider-Shalit T, Louzoun Y, Quintana FJ, Vadai E, Eisenbach L, Cohen IR.

PLoS One. 2009 Jun 25;4(6):e6053. doi: 10.1371/journal.pone.0006053.


Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays.

Merbl Y, Kirschner MW.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2543-8. doi: 10.1073/pnas.0812892106. Epub 2009 Jan 30.


Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis.

Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18889-94. doi: 10.1073/pnas.0806310105. Epub 2008 Nov 21.


Association of the RGS2 gene with extrapyramidal symptoms induced by treatment with antipsychotic medication.

Greenbaum L, Strous RD, Kanyas K, Merbl Y, Horowitz A, Karni O, Katz E, Kotler M, Olender T, Deshpande SN, Lancet D, Ben-Asher E, Lerer B.

Pharmacogenet Genomics. 2007 Jul;17(7):519-28.


Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics.

Merbl Y, Zucker-Toledano M, Quintana FJ, Cohen IR.

J Clin Invest. 2007 Mar;117(3):712-8.


Association of the dopamine receptor interacting protein gene, NEF3, with early response to antipsychotic medication.

Strous RD, Greenbaum L, Kanyas K, Merbl Y, Horowitz A, Karni O, Viglin D, Olender T, Deshpande SN, Lancet D, Ben-Asher E, Lerer B.

Int J Neuropsychopharmacol. 2007 Jun;10(3):321-33. Epub 2006 May 31.


Functional immunomics: microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes.

Quintana FJ, Hagedorn PH, Elizur G, Merbl Y, Domany E, Cohen IR.

Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14615-21. Epub 2004 Aug 12.