The Merbl Lab

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Open positions

We are searching for ambitious and dedicated candidates who are self-driven, highly motivated and able to work independently as well as part of a team. We combine cutting–edge technologies in immunoproteomics, biochemical immunology, cell biology and genomics to address fundamental as well as transnational questions related to proteostasis control of cancer and immune regulation.

Postdoctoral Research Fellow: single cell proteomics

A post-doctoral position for a highly motivated and team-oriented candidate to establish a workflow for Single Cell Proteomics and applying it to various projects in the field of onco-immunology both for basic and translational research. 

Candidates with a PhD in Molecular Biology, Immunology, Biotechnology, or Biochemistry earned within the last two years are encouraged to apply. Proven hands-on experience in wetlab work, immunological assays and FACS sorting is a must. Hands-on experience in mass spectrometry-based proteomics is highly advantageous. Proven experience in integrating solutions for system establishment and background in bioinformatics are required.

The postdoctoral position will be co-supervised by Dr. Yifat Merbl, Department of Immunology and Dr. Yishai Levin, Head of the Protein Profiling unit, the Nancy and Stephen Grand Israel National Center for Personalized Medicine, both at the Weizmann Institute of Science.

The Merbl laboratory takes a multi-disciplinary approach to understanding mechanisms of the ubiquitin-proteasome system in cancer and immune regulation. The Protein Profiling unit houses cutting edge mass spectrometry and informatics for quantitative proteomics and analysis of posttranslational modifications. 

For this position applicants should send a single PDF file to yifat.merbl@weizmann.ac.il and Yishai.levin@weizmann.ac.il, that includes a personal statement of scientific interests and goals (2-page maximum), Curriculum Vitae with recent publications and contact information of three referees.

Project I: Golgi Apparatus-Related degradation

We are looking for a cell biologist to study the role of the ubiquitin-proteasome system in the maintenance and organization of the Golgi apparatus and elucidating novel regulation of the newly identified Golgi stress response. The project will involve cell and molecular biological approaches, complemented by mouse genetic models. Experience in CRISPR and microscopy techniques is advantageous. Applicants should have a PhD in biology, biochemistry, cell biology or a related subject.

 

Project II: E3 ligases in immune signaling

We are looking for a structural biologist (ideally with some electron microscopy experience) to study novel enzymes regulating immune signaling. The project will be centered on a structural biology approach to study Ub ligase complexes.

 

Projects III+IV: Cancer vaccines and sensitizing response to immunotherapy

We are looking for an MD or PhD to utilize our novel immune-proteomics approaches to design novel treatments for cancer therapy. Knowledge and experience in immunology/cancer biology and experience with in vivo models is advantageous. Applicants should have a PhD in immunology, cancer biology or a related subject. MD scientists with a keen interest in life science research are also welcome to apply.

 

Informal inquiries can be directed to avital.eisenberg@weizmann.ac.il

Formal applications, including a CV, the names and contact details of three referees and a concise description of research interests and future plans should be addressed to: yifat.merbl@weizmann.ac.il